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PT-141

PT-141

The arousal peptide—ideal for men and women.

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What is PT141 ?

PT-141 (Bremelanotide)is a centrally acting melanocortin receptor agonist used to enhance sexual desire and arousalin both men and women. Originally developed to treat sexual dysfunction, it is FDA-approved for hypoactive sexual desire disorder (HSDD) in premenopausal women and is also commonly used off-label in men with low libido or erectile dysfunction—especially when psychological or central causes are suspected. Unlike traditional ED medications, PT-141 works through the brain rather than blood flow.

How does it work?

  • PT-141 stimulates the brain’s arousal centers through the melanocortin system:
  • CNS-Based Arousal Enhancement
    • PT-141 activates melanocortin receptors (MC3R and MC4R) in the hypothalamus, increasing sexual desire and drive by acting on the central nervous system.
  • Independent of Blood Flow
    • Unlike PDE5 inhibitors (like sildenafil or tadalafil), PT-141 does not depend on nitric oxide pathways or vascular mechanisms—making it effective for both genders and for arousal-related dysfunction.
  • Rapid, On-Demand Effect
    • Administered via subcutaneous injection 45–60 minutes before sexual activity, PT-141 enhances arousal, responsiveness, and sensitivity for several hours.

Side effects and Precautions

  • Common Side Effects:
    • Nausea (transient)
    • Flushing or warmth
    • Headache
    • Injection site reactions
  • Less Common / Monitor If Present:
    • Elevated blood pressure (temporary)
    • Fatigue or yawning
    • Dizziness
    • Darkening of gums or skin (rare with prolonged use)
How it works
Step 1

Take the health questionnaire

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Step 2

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Step 3

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Frequently Asked Questions

How does PT141 work ?

PT-141 stimulates the brain’s arousal centers through the melanocortin system